Rbm38 hif1
WebNov 16, 2014 · HIF1 belongs to a subfamily of the basic-helix-loop-helix-PAS transcription factors . In response to high levels of oxygen, HIF1α protein is modified by prolyl hydroxylase and rapidly degraded through the VHL-mediated proteasomal pathway . Once ... RBM38 prevents eIF4E from binding HIF1α transcript (A) ... WebFrom the oncology field is known that Rbm38 has a role in the stabilization of the cell cycle inhibitor p21. 8, 25 Indeed we found silencing of Rbm38 to significantly inhibit p21 levels which was ...
Rbm38 hif1
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WebTogether, our data suggest that RBM38 is a novel translational regulator of HIF1α under a hypoxic condition. Author(s): Cho, Seong-Jun; Teng, I-Fang; Zhang, Min; Yin, Tiffany; Jung, … Webfrom publication: Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNAbinding protein and a p53 family target, ... (HIF1), a heterodimeric transcription factor, ...
WebThe possibility of targeting and integrating RBM38 and LXR-α as a therapeutic approach against car-diac remodeling has never been investigated. Herein, we provide evidence to support that RBM38 is a potential modulator of myocardial hypertrophy via the LXR-α-Dependent lipogenesis pathway. WebDiscovery. The HIF transcriptional complex was discovered in 1995 by Gregg L. Semenza and postdoctoral fellow Guang Wang. In 2016, William Kaelin Jr., Peter J. Ratcliffe and Gregg L. Semenza were presented the Lasker Award for their work in elucidating the role of HIF-1 in oxygen sensing and its role in surviving low oxygen conditions. In 2024, the same three …
WebFeb 15, 2024 · Rbm38 is a p53 target and an RNA-binding protein known to suppress p53 translation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to p53 mRNA. In this study, we show that synthetic peptides corresponding to the binding interface between Rbm38 and eIF4E, including an 8 amino acid peptide (Pep8) derived … WebNov 23, 2024 · Objective The study is to research how miR-34-SIRT1 is regulated during hypoxia in lung cancer cells. Results Analysis of publicly available datasets from patients …
WebAug 17, 2012 · RBM38 was shown to be necessary for proper p53 function, ... may be resistant to hypoxia not only because of decreased apoptosis and senescence but also because of increased HIF1 signalling, ...
WebFeb 15, 2024 · The p63 transcription factor, a p53 family protein, regulates genes involved in various cellular processes, including cell growth and differentiation. We previously showed that RNA-binding motif protein (Rbm38) is a p63 target and, in turn, regulates p63α mRNA stability by binding to the AU/U-rich e … dealership start ups saabkyle04WebFunction of RBM38 in human cancer phenotypes a Under hypoxia of lung cancer cells in vitro, HIFα and RBM38 are induced and the former upregulates SIRT1 to inhibits tumor … general licence int/2022/2252300WebJan 6, 2015 · PDF Hypoxia-inducible factor 1 (HIF1), a heterodimeric transcription factor, ... Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNAbinding protein and a p53 … dealerships selling used carsWebHypoxia-inducible factor 1 alpha is regulated by RBM38, a RNA-binding protein and a p53 family target, via mRNA translation Seong-Jun Cho 1 ... HIF1 alpha (HIF1α) and HIF1β … general licence - int/2022/1552576WebDownload scientific diagram RBM38 directly binds to HIF1α 5′ and 3′ UTRs. (A) Whole cell lysates from H1299 cells were collected and immunoprecipitated with anti-RBM38 … dealership software freeWebHypoxia-inducible factor 1 (HIF1), a heterodimeric transcription factor, consists of HIF1α and HIF1β and is necessary for cell growth and survival under a hypoxic condition. ... Furthermore, we showed that knockdown of RBM38 increased, whereas ectopic expression of RBM38 decreased, the binding of eIF4E to HIF1α mRNA. Together, ... general library university of tokyoWebFeb 15, 2024 · Rbm38 is a p53 target and an RNA-binding protein known to suppress p53 translation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to … general licence birds wales