Thiotetroamide

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August undefined, 2024

WebAug 17, 2024 · Enzymatic oxidation–amidation cascade: Uncovering the biochemical genesis of the terminal amide group of thiotetroamide C illuminated a uniquely adapted … WebJan 1, 2024 · Of the 211 705 sequenced bacterial genomes, most represent human pathogens from the Firmicutes and Gammaproteobacteria phyla. By contrast, less than 10% of publicly available sequenced bacterial genomes belong to the prolific NP-producing Actinobacteria phylum.

[PDF] Synthesis, bioactivity, and enzymatic modification of ...

WebOct 1, 1987 · PDF On Oct 1, 1987, L.G. Wayne and others published Report of the Ad Hoc Committee on Reconciliation of Approaches to Bacterial Systematics Find, read and cite all the research you need on ... WebAbstract The selective activation of unreactive hydrocarbons by biosynthetic enzymes has inspired new synthetic methods in C−H bond activation. Herein, we report the unprecedented two‐step biosynth... here\u0027s the thing shirt

Enzymatic C‐H Amidation in the Production of Natural and …

WebThioamide. A thioamide (rarely, thionamide, but also known as thiourylenes) is a functional group with the general structure R1−C (=S)−NR2R3, where R1, R2 and R3 are any groups … WebMar 12, 2024 · In the biosynthesis of thiotetroamide produced by Streptomyces afghaniensis NRRL 5621, TtmP P450 converts the terminal C-H bond of the C-4 ethyl … Webgene cluster from Salinispora pacifica CNS-863 and the thiotetroamide gene cluster from Streptomyces afghaniensis NRRL 5621 have been deposited in the GenBank database (accession nos. KT282100 and KT282101, respectively). HHS Public Access Author manuscript ACS Chem Biol. Author manuscript; available in PMC 2016 December 18. matthias monden

Enzymatic C−H Oxidation–Amidation Cascade in the …

thiotetroamide C CTD

WebMar 12, 2024 · The macrolide P450 enzymes TylI and Srm13 are involved in oxidation reaction leading to the formation of hydroxymethyl and formyl groups in the biosynthetic pathways of tylosin and spiramycin produced by Streptomyces fradiae ATCC 19609 and Streptomyces ambofaciens, respectively (Table 1; Fig. 3b, c) (Baltz et al. 1983; Nguyen et … WebSep 1, 2024 · Four new triterpenoid saponins, clematochinenoside H–K (1–4), and five known structures (5–9), were isolated from the roots and rhizomes of Clematis chinensis. Their structures were elucidated on... matthias moos burbachWebThe selective activation of unreactive hydrocarbons by biosynthetic enzymes has inspired new synthetic methods in C‐H bond activation. Herein, we report the unprecedented two‐step biosynthetic conversion of thiotetromycin to thiotetroamide C involving the tandem carboxylation and amidation of an unreactive ethyl group. matthias montangerand

"WebA focused library of 17 novel thiotetromycin derivatives differing at the 5-position alkyl substituent is synthesized to investigate their biological activities and their reactivity towards the hydroxylase TtmP, an interesting target for P450 engineering towards broader applications. Thiotetronate-containing natural products, including thiolactomycin, … " - Thiotetroamide

Thiotetroamide

Enzymatic C−H Oxidation–Amidation Cascade in the Production …

WebThis review highlights several of the opportunities provided by genome sequencing and bioinformatics, challenges associated with translating genomes into natural products, and examples of successful strain prioritization and BGC activation strategies that have been used in the genomic era for natural product discovery from cultivatable bacteria. WebWe detail the genetic and biochemical basis for the terminal amidation in thiotetroamide C biosynthesis, which involves a uniquely adapted cytochrome P450–amidotransferase enzyme pair and highlights the first oxidation–amidation enzymatic cascade reaction leading to the selective formation of a primary amide group from a chemically inert alkyl …

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WebDownload scientific diagram Biosynthetic conversion of thiotetromycin to thiotetroamide C catalyzed by TtmP and amidotransferase. P450s are shown in red. The functional groups … WebAn unprecedented two-step biosynthetic conversion of the natural product thiotetromycin to thiotetroamide C involving the tandem oxidation and amidation of an unreactive alkyl group has been reported. 28 This is the first report of an oxidation–amidation enzymatic cascade reaction leading to the selective formation of a primary amide group ...

WebThiotetronate-containing natural products, including thiolactomycin, thiotetromycin, and thiotetroamide, are potent, broad-spectrum antibacterial compounds that target fatty acid … http://ctdbase.org/detail.go?type=chem&acc=C000630558

WebMar 16, 2024 · Europe PMC is an archive of life sciences journal literature. WebNational Center for Biotechnology Information

WebAug 17, 2024 · We detail the genetic and biochemical basis for the terminal amidation in thiotetroamide C biosynthesis, which involves a uniquely adapted cytochrome …

WebBGC0001236. Short description. thiotetroamide biosynthetic gene cluster from Streptomyces afghaniensis. Status. Minimal annotation: yes. A minimal annotation only … matthias montoroWebThiotetronate-containing natural products, including thiolactomycin, thiotetromycin, and thiotetroamide, are potent, broad-spectrum antibacterial compounds that target fatty acid synthesis in ... matthias morrWebAug 17, 2024 · We detail the genetic and biochemical basis for the terminal amidation in thiotetroamide C biosynthesis, which involves a uniquely adapted cytochrome P450–amidotransferase enzyme pair and highlights the first oxidation–amidation enzymatic cascade reaction leading to the selective formation of a primary amide group from a … here\u0027s the thing 意味WebSubsequently, a group of NPs featuring a rare thiotetronic acid moiety, including the previously reported fatty acid synthase inhibitor thiolactomycin (TLM) as well as three analogues (one novel), were isolated (Figure 5B).[49, 50] A second BGC, the thiotetroamide (ttm) BGC from S. afghaniensis, was similarly cloned due to its resemblance to ... matthias moosdorf bundestagWebThiotetronate-containing natural products, including thiolactomycin, thiotetromycin, and thiotetroamide, are potent, broad-spectrum antibacterial compounds that target fatty acid … matthias moosdorfWebEnzymatic oxidation–amidation cascade: Uncovering the biochemical genesis of the terminal amide group of thiotetroamide C illuminated a uniquely adapted cytochrome P450–amidotransferase enzyme pair t... matthias morr schwulWebUnfortunately, serious adverse effects associated with thioamides in humans include idiosyncratic liver damage, agranulocytosis, aplastic anemia, and vasculitis. matthias morr facebook